The focus of development is shifting from the global to the regional level. The main trends of the foreseeable future – the fragmentation of the world political order, the regionalization of economic relations and the international legal system, the emergence of new mechanisms of cooperation – are the main topic of the new issue of trendletters, produced as part of a joint project of the Human Capital Multidisciplinary Research Center and the UNESCO Futures Studies Chair (UNESCO Futures Literacy Chairs network).